As treatment options for obstructive sleep apnea (OSA) continue to evolve, questions remain about their effectiveness. Dr. Raj C Dedhia, recruited from Emory University in 2019, currently serves as Director of the Sleep Surgery Division. He spends 50% of his time as a sleep researcher, studying better ways to predict response to OSA surgery and the effects current therapies may have on patient health. He currently receives funding from the National Institutes of Health, American Heart Association, American Academy of Sleep Medicine, and Triological Society.
Sleep Surgery Research Team
Everett Seay, BS, RPSGT
Senior Research Coordinator
Akshay Tangutur, MS
Yifan Liu, MD
Active Research Projects
Characterizing Mechanisms of Upper Airway Obstruction During Drug-Induced Sleep Endoscopy
Drug-induced sleep endoscopy (DISE) is a procedure used by Otolaryngologists to evaluate upper airway collapse site(s) of patients with obstructive sleep apnea. Our National Institutes of Health (NIH) sponsored study aims to characterize specific causes of upper airway obstruction during DISE. Our approach involves measuring airway pressures, pharyngeal patency, airflow, and responses to tongue muscle stimulation during DISE. Our goal is to develop personalized solutions that address the pathogenic mechanisms of airway collapse and airflow obstruction during sleep.
Raj Dedhia, MD, MSCR and Alan Schwartz, MD are joint Principal Investigators on this project.
Hypoglossal Nerve Stimulation on Cardiovascular Outcomes
A new, well-tolerated treatment known as tongue stimulation is a device which opens the airway during sleep and can provide treatment for patients unable to use the mask and hose treatment. This study will evaluate the effect of this new treatment on blood pressure and heart-related measures to observe if it lowers patients’ risk of heart problems. To learn more about the methods, please read this publication by Dr. Dedhia’s team: https://www.ncbi.nlm.nih.gov/pubmed/30194765
Sleep Surgery on Blood Pressure and Peripheral Arterial Tonometry
This study will evaluate the effects of upper airway surgery on cardiovascular function as measured by changes in blood pressure and peripheral arterial tonometry before and after treatment.
CPAP Level Differences Among Apnea-Predominant Versus Hypopnea-Predominant Obstructive Sleep Apnea Patients
In this retrospective study, we investigate the average CPAP levels between apnea-predominant and hypopnea-predominant OSA patients to determine if there are differences in their therapeutic CPAP requirements.
The Role of Craniofacial Maldevelopment in the Modern OSA Epidemic
In this systematic review, we are looking into how evolution, heredity, and environment have contributed to craniofacial development with the hopes to better understand how these factors may predispose humans to develop obstructive sleep apnea (OSA). We hope that understanding these influences, particularly of environmental factors, can lead to preventative measures to decrease OSA risk.
Raj Dedhia, MD, MSCR and Jason Yu, MD are joint Authors on this project.
Mentored Projects under Dr. Dedhia
“Evaluation of Therapeutic Positive Airway Pressure as a Hypoglossal Nerve Stimulation Predictor in Patients With Obstructive Sleep Apnea.”
“Upper airway surgery to rescue the “untitratable” patient with OSA and obesity.” https://www.ncbi.nlm.nih.gov/pubmed/31957643/
Lead Author: Everett Seay, BS, RPSGT
“Success of Hypoglossal Nerve Stimulation Using Mandibular Advancement During Sleep Endoscopy.” https://onlinelibrary.wiley.com/doi/full/10.1002/lary.28589
Lead Author: Graeme Mulholland, MD, FRCSC
“Obstructive sleep apnea, sleep symptoms, and their association with cardiovascular disease.” https://www.ncbi.nlm.nih.gov/pubmed/31532856
Lead Author: Melissa Oh, MD
“Transoral Versus Endoscopic Examination in Predicting Outcomes of Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea.” https://pubmed.ncbi.nlm.nih.gov/32533788/
“Therapeutic Positive Airway Pressure Level Predicts Response to Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea.” https://www.ncbi.nlm.nih.gov/pubmed/31482839
Lead Author: Clara Lee, MD
“Hypoglossal Nerve Stimulation Therapy on Peripheral Arterial Tonometry In Obstructive Sleep Apnea: A Pilot Study.” https://www.ncbi.nlm.nih.gov/pubmed/?term=29926395
Lead Author: Allison Ikeda, MD
“Practice Patterns of Sleep Otolaryngologists at Training Institutions in the United States.” https://www.ncbi.nlm.nih.gov/pubmed/27677599
“Validated Measures of Insomnia, Function, Sleepiness, and Nasal Obstruction in a CPAP Alternatives Clinic Population.” https://www.ncbi.nlm.nih.gov/pubmed/28633723
Lead Author: Austin Lam, MD
“Surgical Treatment of OSA on Cardiovascular Outcomes: A Systematic Review.” https://www.ncbi.nlm.nih.gov/pubmed/28923761
Lead Author: Tyler Halle, MD
“Sedative Choice In Drug-Induced Sleep Endoscopy: A Neuropharmacology-Based Review.” https://www.ncbi.nlm.nih.gov/pubmed/27363604
Lead Author: Jack “Will” Shteamer, MD